Applied Object

To prevent Avian Influenza, improve poultry's immunity and growth performance for poultry farm.

Present Situation of Avian Influenza Worldwide

In 2004, the shadow of SARS had not faded away, then the surge of Avian Influenza affected people again.

Avian Influenza's wilful persecution

v        During 2003 and 2004, Avian Influenza spread over dozens of countries, and peoples from 16 provinces in China were diagnosed infected by Avian Influenza.

v        Large quantities of poultry were killed or died, which led to the serious impact for poultry breeding.

v        Since 1997, over 40 persons from the world died of Avian Influenza, which seriously threatens human's life safety.

v        Once applied vaccine to poultry, poultry's serum antibody present positive. The circulating and exporting of such poultry product will be restricted.

KEQINLING is  the great breakthrough in the environmental-friendly drug research of preventing Avian Influenza.

Overflow of Newcastle Disease

Newcastle Disease was once the most grievous and overspread poultry disease in China. Recent years, due to the extensive application of vaccine, the outbreak of typical Newcastle Disease were controlled. However, owing to various reasons, such as vaccine's quality, kind, dosage, inoculation, interference factor, immune response, and carelessness during transportation and storage, the immune effect is not as perfect as expectation, and it leads to spreading of the non-typical Newcastle Disease, which presents new characters of symptom, pathological changes, incidence rate and death rate. These causes unmeasurable lost of the poultry breeding industry.

Characters of Avian Influenza and Newcastle Disease

Avian Influenza is the poultry infection or disease syndrome caused by Avian Influenza virus A. According to antibody difference of Hemagglutinin and Neuramidinase of Avian Influenza virus, it can be sorted into different subtypes. Avian Influenza is also one kind of immunosuppressive diseases, the sick chicken group mostly infects other intercurrent or secondary disease, such as Avian Colidecillosis, Newcastle Disease, and Infectious Bronchitis. These diseases represent as poultry's systemic or respiratory system disease and accompanied by symptoms of diarrhea. Home-poultry such as chicken, turkey, duck and quail, and wild bird, water bird, seabird, all could be infected.

Characters of Avian Influenza virus: 1. Particularly has many serotype: H1-15、N1-9, common serotype: H1N1, H4N2, H5N1, H5N2, H7N7, H9N3. 2. Different subtypes have different nosogenetic. Avian Influenza virus has strong mutagenicity, the virus antigen is liable to variate (antigenic drift, gene recombine), and it is lack of cross immunity response from virus strain of heterologous serotype.

Non-typical Newcastle Disease: Newcastle Disease is caused by Avian Paramyxoviridae Virus I, which is a destructive infectious poultry disease. It can infect many kinds of poultries, especially chicken, in despite of neither chicken breed nor age. It can occur all around the year, infect through respiratory tract or digestive tube and immediate contact. According to the pathogenesis, such as virulence of virus, infective conditions and environment, the disease is varied in symptom and duration of illness. The character usually presents the non-typical in fact.

Characters of Newcastle Disease virus: The virulence of different virus strain of homologous serotype varies a lot.

Corresponding Measurements

è       Strengthen the inspection, establish the integrated prevention system; prevent the introduction of high pathogenicity influenza virus, and strictly carry out the policies of isolation and kill the sick poultry.

è       Inoculating vaccine is the most popular corresponding measurement for poultry farm. However, there are so many serotype of Avian Influenza, and the virus has a rather strong mutagenicity, then there is no cross-protection among different vaccine serum. Therefore, the application of Avian Influenza vaccine is still forbidden in some developed countries. Owing to various reasons, the immune effect of Newcastle Disease vaccine is not as perfect as expectation, and it leads to spreading of the non-typical Newcastle Disease, thus, the vaccine effect is rather limited.

è       Strengthen the feeding management and feed nutrient, reduce the stress, and adopt drug defending (reinforce disinfections, and improve poultry's self- resistance), are the effective way to prevent Avian Influenza. (But, such specific medicine to improve poultry's self-resistance has never been produced.)

The above measurements cannot solve the problems we face! With such plight, the breeding industry needs a product to effectively prevent virosis such as Avian Influenza, and improve animal's immunity!

Product Characters

KEQINLING is a natural feed additive of herbal extract

KEQINLING is made from various natural botanic materials, which can improve immunity, restrain virus, promote growth, and help remove stagnated food by using stamachics. Without any addition of chemical component, KEQINLING is a natural, environmental-friendly, residue-free, pollution-free feed additive.

KEQINLING is produced through cell-disruption technology

The modern high-tech cell-disruption technology is adopted through the production of KEQINLING. When the plant cell wall was broken, over 95% of the plant histiocyte appears as cell fragment seen from the microscope, then the efficacious contents can be adequately released. Over 90% of the product's particle diameter is less than 20μm, and the mean particle diameter extents from 6 to 8μm. It is a micron-class Chinese herb, which can be evenly distributed and dissolved in intestinal juice, so as to improve the absorption rate.

Cell-disruption technology can retain the material basis of bioactivity while keep efficacious contents' chemical structure unchanged, so as to promote the dissolve speed of efficacious contents and biologic utilizing rate, and reach the maximum value.

Basis of formulating prescription

According to Chinese medicine principle----supporting healthy energy to eliminate evils, and aiming at the characters of poultry virosis, this formula is consisted of natural botanic materials, which can clear away pathogenic heat and remove the toxin, strengthen spleen and reinforcing Downward Perversion of Qi, stimulate the metabolism and improve organism's nonspecific immunity function. Being scientifically formed, KEQINLING can increase poultry's anti-disease ability, so as to accomplish the purpose of preventing disease.

Ingredients

This product contains various natural botanic efficacious contents, such as flavonoids, alkaloid, organic acid, polysaccharide, volatile oil.

Product Function

Prevent Avian Influenza: During the chook experiment of artificial infecting high pathogenicity Avian Influenza virus strain H5N1, the death rate of the group without drug was 83.3～86.7%, the death rate of the group treated 2‰ KEQINLING was 13.3～23.3%, which substantial reduces the death rate by 70～85% (p<0.01). KEQINLING can succeed protect poultry against AI by 76.7～86.7 %（p<0.01）, which was the great breakthrough in the drugs research of preventing Avian Influenza.

Improve organism's immunity

Only add 1‰ KEQINLING can increase T lymphocyte ANAE positive rate by 8.5～9.3％, and improve organism's cell-mediated immune level.

Add 1‰ KEQINLING while inoculating vaccine can strengthen the immunity as immunopotentiator, and improve organism's immune response ability

When inoculate Newcastle Disease vaccine, it can increase T lymphocyte ANAE positive rate by 5.7% for the first inoculation, 9.1% for the second inoculation, and improve Newcastle Disease HI antibody value by5.1%; When inoculate Avian Influenza vaccine, it can increase T lymphocyte ANAE positive rate by 12.7% （p<0.05）for the first inoculation, 16.2% （p<0.05）for the second inoculation, and improve Avian Influenza HI antibody value by 5.9%;

Prevent secondary disease as bacterial infection

Has favorable effect to prevent later paroxysmal Avian Colidecillosis

resulted from the weak immunity.

Improve performance, promote growth

Evidently improve chicken's ADG by 12.6%（p< 0.01）, decrease feed/meat rate by 9.5%, which has great effect to promote growth.

Product's Comparative Advantages

n         This product is the latest fruit of Guangdong VTR Bio-tech Co., Ltd. and Zhongshan University.

n         VTR company has founded a provincial class scientific research institution “Feed Additive Bioengineering Technology Research and Development Center of Guangdong”, and set up many united research institutes with many universities and academes, with which VTR company can provide powerful technology backup for the product.

n         Provide the poultry with resistance against virosis such as Avian Influenza while without inoculation of vaccine.

n         Avoid serum antibody presenting positive of poultry product when checked, compared with that inoculated vaccine, thus it promotes the export to countries which restrict the application of vaccine, such as Singapore, Thailand, Malaysia, Korea, Japan in South East Asia, and nations of European Union.

n         This product is produced in GMP workshop, and the whole produce process is under monitor supervision, which guarantees the traceability of each process.

n         The modern high-tech cell-disruption technology is adopted through the production of KEQINLING. Then the plant cell wall is broken, so as to promote the dissolve speed of efficacious contents and biologic utilizing rate, and reach the maximum value.

n         The product standard introduces the standard of modern Chinese Pharmacopoeia, and also reference on the standard of Europe, America and Japan. The company has built up the fingerprint analysis of TCD, and adopted the advanced inspecting equipment to monitor and control the quality, all these guarantee the batch stability and high quality.

n         This product is made from various natural botanic materials. Without any addition of chemical drug ingredients, KEQINLING is an environmental-friendly, pollution-free, residue-free, drug-resistance-free feed additive of herbal extract.

Instructions

Usage

Ø         Directly add into feed, keep palatability unchanged.

Ø         Premix this product with 10 times feedstuff, and then add it to the large quantities and mix to be even.

Dosage

Ø         Prevent Avian Influenza: Add 2kg into 1000kg feed.

Ø         Improve immunity: Add 1kg into 1000kg feed.

Ø         Improve performance: Add 0.5~1kg into 1000kg feed

Precautions

Ø         Use this product immediately after opened. The remainder should be sealed stored.

Ø         Keep away from rain, moisture and sunlight when transported, keep in cool and dry place.